Why are mRNA vax effective against severe Covid?

A team of US researchers has explored the success behind the new mRNA vaccine technology used by Pfizer and Moderna to make vaccines against Covid.

The vaccines have arguably been the most effective Covid vaccines developed to date. In clinical trials, both were more than 90 per cent effective in preventing symptomatic infection.

Even with the Delta and Omicron variants, the vaccines remain quite effective at preventing hospitalisation and deaths.

In the study, researchers from Washington University School of Medicine in St. Louis and St. Jude Children’s Research Hospital showed that the Pfizer vaccine strongly and persistently activates a kind of helper immune cell that assists antibody-producing cells in creating large amounts of increasingly powerful antibodies, and also drives the development of some kind of immune memory.

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